St. John’s Wort (Hypericum perforatum) is a plant known for its medicinal properties. It contains a variety of active substances, including:
Hypericins and hyperforins:
These compounds are considered the main contributors to the therapeutic effects of St. John’s Wort. They act as monoamine oxidase inhibitors (MAOIs) and are involved in regulating serotonin, dopamine, and norepinephrine levels in the brain.
Flavonoids:
St. John’s Wort contains a wide range of flavonoids, including quercetin, rutin, hyperoside, and isoquercitrin. These substances have antioxidant and anti-inflammatory properties.
Tannins:
St. John’s Wort contains tannins, which are organic compounds with astringent properties. They may have beneficial effects on the health of the digestive system.
Volatile oil:
The essential oil extracted from St. John’s Wort contains substances such as alpha-pinene, cadinene, and germacrene D, which may have antimicrobial and anti-inflammatory effects.
Chlorogenic acid:
Chlorogenic acid is a phenolic compound present in St. John’s Wort. It has antioxidant properties and may play a role in protecting cells against oxidative stress. These components of St. John’s Wort work together to produce the therapeutic effects of the plant. St. John’s Wort is often used as a dietary supplement or standardized extract in the treatment of mild to moderate depression, anxiety, sleep disorders, and other conditions. It is important to consult a doctor or specialist before using St. John’s Wort or any supplement, as it may interact with other medications and can have side effects in certain situations. St. John’s Wort tea is often used to improve mood and help manage symptoms of mild to moderate anxiety and depression. This effect is attributed to several active substances found in St. John’s Wort, such as hypericins and hyperforins. Clinical studies have shown that St. John’s Wort tea can have antidepressant and anxiolytic effects. It is believed that these active substances influence the levels of neurotransmitters in the brain, such as serotonin, dopamine, and norepinephrine, which play an important role in regulating mood and anxiety.
Drinking St. John’s Wort tea may help with:
1. Improving mood:
Research suggests that St. John’s Wort tea can reduce symptoms of mild to moderate depression, including sadness, low mood, and lack of interest or pleasure in activities.
2. Reducing anxiety:
St. John’s Wort tea may have a calming and relaxing effect, helping to reduce symptoms of anxiety, such as restlessness, agitation, and nervous tension.
3. Alleviating sleep disorders associated with anxiety or depression:
Some individuals may experience sleep disturbances, such as insomnia or fragmented sleep, as a result of anxiety or depression. St. John’s Wort tea may help induce sleep and improve sleep quality.
4. Antidepressant effect:
Clinical studies have demonstrated that St. John’s Wort extracts can be effective in alleviating symptoms of mild to moderate depression. The active substances in St. John’s Wort, such as hypericins and hyperforins, may influence the levels of neurotransmitters in the brain, including serotonin, dopamine, and norepinephrine, which are involved in regulating mood.
5. Stimulating serotonin levels:
St. John’s Wort may increase serotonin levels in the brain, a neurotransmitter associated with well-being and emotional regulation. Low serotonin levels may be involved in the development of depression, and St. John’s Wort may help balance this.
6. Reducing anxiety:
St. John’s Wort has a calming and anxiolytic effect, which may help reduce anxiety levels.
It is important to note that St. John’s Wort can be effective in treating mild to moderate depression but is not recommended for severe depression. Additionally, caution is necessary when using St. John’s Wort in combination with other medications, as there may be a risk of interactions and side effects. The main recommendation is to always consult a doctor or mental health specialist before using St. John’s Wort or any other supplement for treating depression.
There are several St. John’s Wort preparations available to benefit from its therapeutic properties. Here are some common options:
St. John’s Wort infusion:
The infusion is the simplest method to benefit from the therapeutic effects of St. John’s Wort. Add 1-2 teaspoons of dried St. John’s Wort flowers to a cup of hot water. Let it steep for 10-15 minutes, then strain the liquid. Drink St. John’s Wort infusion 2-3 times a day. This can be used to obtain antidepressant benefits, reduce anxiety, and alleviate sleep disturbances associated with depression.
It is important to note that the effects of St. John’s Wort tea may vary from person to person and can be influenced by various factors, such as dosage and duration of consumption. Additionally, St. John’s Wort tea is not recommended for severe depression or as a substitute for prescribed medication. Before using St. John’s Wort tea to improve mood or treat mental health conditions, it is always recommended to consult a doctor or a mental health specialist.
St. John’s Wort extract:
St. John’s Wort extract is a concentrated preparation that can be purchased in capsule or liquid form. These extracts are standardized to contain specific amounts of active compounds from St. John’s Wort, such as hypericins. Follow the instructions on the label or consult a specialist to determine the appropriate dosage based on your needs.
St. John’s Wort oil:
St. John’s Wort oil is a concentrated extract obtained by macerating the flowers in oil. It can be applied topically to the skin to treat burns, superficial wounds, or skin irritations. St. John’s Wort oil may also have a mild calming and relaxing effect. St. John’s Wort oil:
Step 1: Collecting the plants Gather fresh St. John’s Wort flowers during their flowering season. Make sure to select healthy and uncompromised plants.
Step 2: Drying the plants Spread the flowers in a thin layer in a cool, well-ventilated place, away from direct sunlight. Allow the flowers to dry completely until they feel brittle to the touch.
Step 3: Macerating the flowers in oil Place the dried flowers in a clean, sterilized glass jar. Cover them completely with a pure, high-quality oil, such as olive oil or sunflower oil. Ensure that the flowers are completely submerged in oil and that no areas are exposed to air.
Step 4: Infusing the oil Seal the jar tightly and let it sit in the dark for about 4-6 weeks. This time allows the active substances from St. John’s Wort to infuse into the oil.
Step 5: Filtering and storing After the infusion period, strain the oil to remove the flower residues. Use a fine sieve or clean cheesecloth. Transfer the infused oil into an airtight glass container and store it in a cool, dark place. The obtained St. John’s Wort oil can be used externally for application on the skin.
Capsules or tablets:
St. John’s Wort is also available in capsule or tablet form, which contains St. John’s Wort extract. These can be taken orally, following the instructions on the label or the recommendations of a doctor.
Caution
St. John’s Wort (Hypericum perforatum) may have significant interactions and contraindications, especially when used in conjunction with other medications. It is essential to always consult a doctor or pharmacist before using St. John’s Wort or any St. John’s Wort-based supplement. Here are some of the main contraindications and precautions associated with St. John’s Wort:
Drug interactions:
St. John’s Wort may interact with numerous medications, including oral contraceptives, anticoagulants (such as warfarin), antidepressants, immunosuppressive medications, blood pressure medications, and others. These interactions may reduce the effectiveness of medications or have other undesirable effects. It is important to inform your doctor about any medications you are taking before using St. John’s Wort.
Adverse reactions and side effects:
The use of St. John’s Wort may cause some side effects, such as gastrointestinal irritation, nausea, headaches, agitation, photosensitivity (increased sensitivity to sunlight), and allergic reactions in some individuals. If side effects or adverse reactions occur, discontinue use and consult a doctor.
Use during pregnancy and breastfeeding:
The safety of using St. John’s Wort during pregnancy and breastfeeding has not been fully established. As a precaution, it is recommended that pregnant or breastfeeding women avoid using St. John’s Wort.
Sensitivity to sunlight:
The use of St. John’s Wort may increase sensitivity to sunlight and may cause skin reactions upon exposure to sunlight or UV rays. It is recommended to avoid prolonged sun exposure and to use adequate sun protection while using St. John’s Wort.
Medical conditions and allergies:
Individuals with medical conditions, such as bleeding disorders, epilepsy, liver or kidney conditions, should consult a doctor before using St. John’s Wort. It is also important to inform your doctor about any allergies or sensitivities you have before using St. John’s Wort.



